Abstract
BackgroundTardive dyskinesia is a serious side effect of antipsychotics’ activity. Imaging of the dopamine transporter could demonstrate the possible involvement of dopaminergic pathway in the appearance of tardive dyskinesia.Methods/resultsWe report a case with paranoid schizophrenia and tardive dyskinesia symptoms. A first trial with quetiapine improved TD symptoms while an increase of its dose after a relapse of the underlying disease deteriorated the TD symptoms. Following that, sertindole was initiated which led to improvement of both psychotic and TD symptoms. A DAT scan showed physiologic distribution in the basal ganglia. Six months later after a serious cardiac syncope, sertindole was discontinued. Quetiapine was then started which led again to TD symptoms. A second DAT scan showed decreased dopamine transporter uptake in the area of basal ganglia.ConclusionWe conclude that decreased dopamine transporter uptake seemed to associate with the deterioration of TD.
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