P0188TOTAL CHOLESTEROL EXCESS DOESN'T AFFECT CORONARY ARTERY CALCIFICATION INDEPENDENTLY OF RENAL FUNCTION

Abstract

Abstract Background and Aims Coronary artery calcium score (CACS) allows to improve significantly predictive value of traditional tools for cardiovascular risk estimation. Reduced renal function is associated with increase of rates of cardiovascular events. Dyslipidemia is an important factor of cardiovascular system injury in chronic kidney disease. The Aim. To investigate association between glomerular filtration rate (GFR), total cholesterol and CACS. Method We performed the study on 170 patients (77 males and 93 females, aged 56 [52;63] years) who underwent CACS at Dnipropetrovsk Mechnikov Regional Hospital, Dnipro, Ukraine, from December 2017 till March 2019. Patients in the study were free of known cardiovascular disease and required reclassification of cardiovascular risk. Patients were subdivided by total cholesterol (TC) level (<5.2 mmol/l, n=83; ≥5.2 mmol/l, n=87) and by GFR (≥90 ml/min, n=64; 60-89 ml/min, n=90; 30-59 ml/min, n=16). CACS was presented in Agatston units (AU). Results Median age in groups by TC was comparable (56 [53;63] vs 56 [51;64] years, p=0.51) and elevated significantly with decline of GFR (54 [49;59], 57 [53;65] and 70 [59;77] years for patients with GFR≥90, 60-89 and 30-59 ml/min respectively, p for trend <0.001). We didn’t observe any statistically significant differences of CACS after patients subdivision, though it was higher in TC≥5.2 mmol/l group. Conclusion We didn’t find convincing data supporting significant impact of TC excess on coronary artery calcification.