Abstract
The “Kanbaku-taiso-to” (KT), mixture of three herbal drugs, Glycyrrhizae Radix, Tritici Semen and Zizyphi Fructus, sometimes shows a marked effect on insomnia and infantile convulsions. The ancient Chinese medical book “Kinkiyoryaku” described the effectiveness of KT on emotional irritability. To elucidate the mechanism of action of KT, neuropharmacological screening tests were performed and the following results were obtained. (i) KT lengthened the hexobarbital sleeping time; (ii) KT showed a marked prolongation of time to death in pentylenetetrazole (PTZ)-induced convulsions; (iii) locomotor activity was inhibited by 7-day continuous administration of KT.These results suggested that KT had a sedative effect on the nervous system.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
