Abstract
Peroxiredoxins (Prxs, 20–30 kDa) belong to the thioredoxin protein family that is characterized by a common structural motif, the thioredoxin fold, and the presence of one or two cysteines in their active site. These proteins are recognized as key molecules in redox signaling and are expressed in various tissues of mice and humans. The growing evidence for a role of oxidative stress in bone pathologies, prompted us to systematically analyze the expression patterns of Prxs (1–6) in the femur of rats and their changes after ovariectomy. All analyzed Prxs were abundantly expressed in different cell types of the bone of sham operated rats. Strong signals for Prx1 and 3 were observed in osteocytes’ lacunae, osteoblasts, bone lining cells, and in the epiphyseal cartilage. Both Prx1 and Prx3 showed a characteristic staining pattern in the canalicular system of the bone. Ovariectomy in rats induced downregulation of Prxs in almost all cell types of the bone and bone marrow compartment. Because these redox proteins are crucial not only for maintaining a reduced environment, but also for many other cellular processes, the results shown here might have an implication in diseases associated with estrogen deficiency, for instance, osteoporosis and the immune response in aging.
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