Abstract
Ethanol withdrawal (EW) increases acetaldehyde accumulation and reactive oxygen species formation that promote damage to the brain. It is necessary to emphasize that while EtOH abuse and dependence are widespread, treatment options are extremely limited. This study aimed at investigating the protective effects of Ozone Oxidative Postconditioning (OzoneOxPost) on brain injury induced by oxidative stress and behavioral changes after 2 weeks of EW in rats. Four groups of rats (n = 10 each one) were settled: (I) Control, (II) Ethanol; (III) Ethanol + Ozone, and (IV) Ethanol + Oxygen. At the end of EW, rats were subjected to behavioral tests followed by brain tissue collection to measure markers of oxidative damage. OzoneOxPost increased food consumption, maintained water intake at the same levels as the control group, and reestablished cellular redox status. Anxiety, locomotor activity, and memory/learning of the rats were improved. These results demonstrated that OzoneOxPost protected the brain against oxidative injury, improving important functions of the Central Nervous Systems (CNS). It is a novel finding that is evidence of ozone's effects on CNS.
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