Abstract
Uterine bleeding was induced by oxymetholone (100 to 200 mg. per day for 3 to 7 days) in a group of women with secondary amenorrhea but sufficient endogenous estrogens. This indicated either interference with ovarian estrogen production, a direct endometrial effect, or both. In the second phase of the clinical experiment, uterine bleeding was also induced in a group of women with complete ovarian failure in whom endometrial growth was promoted by estrogen priming. The ability of oxymetholone to induce uterine bleeding in these patients suggests that this compound can exert endometrial effects directly, without necessarily interfering with the ovarian estrogens. Endometrial histology revealed minimal subnuclear vacuolization with the 100 mg. daily dose and prominent subnuclear vacuolization with the 200 mg. daily dose. The decrease of the karyopyknotic index during oxymetholone treatment was interpreted as an expression of the antiestrogenic properties of the compound.
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