Abstract
Oxyhemoglobin affinity was evaluated in 21 patients with chronic arterial hypoxemia due to pulmonary fibrosis and granulomatosis (sarcoid) by measurements of the blood oxygen tension required to achieve 50 per cent oxyhemoglobin saturation at 37°C and pH 7.40 (P50), erythrocytic 2,3-diphosphoglycerate (2,3-DPG) and adenosine triphosphate. Twelve normal persons served as control subjects. Mean (± SD) physiologic values characterizing these patients included: forced vital capacity, 67.8 ± 17.6 per cent of predicted (P < 0.01); steady state pulmonary diffusing capacity for carbon monoxide, 61.9 ± 14.8 per cent predicted (P < 0.001); arterial oxygen tension = 72.1 ± 13.6 mm Hg (P < 0.001); and hydrogen ion concentration = 36 ± 2.6 mµM per liter (P < 0.001). Carboxyhemoglobin and hemoglobin concentrations were similar in both groups. A decrease in oxyhemoglobin affinity was observed (P50: 28.0 ± 1.6 mm Hg versus control P50: 25.8 ± 0.9 mm Hg; P < 0.001) without parallel increases in erythrocytic 2,3-DPG. Low, ...
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