Abstract
Described here are the progressive changes in blood-flow distribution that accompany four-hour heart-lung bypass in dogs and the effects of perfusion rate on flow distribution and oxygen consumption. The corresponding changes produced by anesthesia alone and by the thoracotomy needed for a bypass procedure are also shown for comparison purposes. These data indicate that the bypass procedure itself puts a very significant stress on the test animals and that perfusion rates in excess of resting cardiac output are required to prevent hypoxia induced irreversible tissue damage.KeywordsCardiac OutputPerfusion RateBypass ProcedureLeft Subclavian ArteryColloidal Osmotic PressureThese keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
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