Abstract
Oxidative Stress in Type 2 Diabetes with Iron Deficiency in Asian IndiansA close relationship exists between iron metabolism, diabetes and oxidative stress. Both diabetes and redox active iron are individually known to enhance oxidative stress. However, the role of iron deficiency and oxidative stress in diabetes is not clear; hence, the levels of oxidative stress in type 2 diabetes with and without iron deficiency have been compared. Two groups of 30 patients each with diabetes were selected (one group with iron deficiency and the other group with normal iron levels) and compared with 30 normal healthy controls. The anthropometric parameters, fasting blood sugar, iron profile and oxidative stress parameters (malondialdehyde levels (index of lipid peroxidation) and serum uric acid levels (antioxidant)) were measured. While the diabetes group had significantly increased serum levels of ferritin (an acute phase reactant and antioxidant) in comparison with normal controls (P=0.040), the diabetic group with iron deficiency had decreased serum levels of iron (P =0.000), ferritin (P = 0.000) and uric acid (P = 0.006) and increased levels of malondialdehyde (P = 0.000) in comparison with diabetics without iron deficiency. This study shows an increase in oxidative stress in the diabetic group with iron deficiency together with reduction in antioxidant levels could further promote prooxidant levels and inflammation and in turn result in the development of complications in this high-risk Asian Indian population.
Highlights
A bi-directional relationship exists between iron and glucose metabolism (1)
Diabetes alters the availability of redox active Fe2+ either from excessive iron stores or from alterations in the protective mechanisms which normally prevent the release of free iron (6)
The haemoglobin levels were normal in both Groups II and III; the diabetes seen in Group II cannot be attributed to iron overload
Summary
Insulin regulates the cellular uptake of micronutrients including iron; iron interferes with the function and metabolism of insulin in the liver (1). 116 Ganesh et al.: Oxidative stress in diabetes with iron deficiency. The presence of iron in reversible oxidized and reduced forms is responsible for its metabolic function and its potential toxicity (4). The redox active, Fe2+, catalyses the generation of a powerful free radical – the hydroxyl radical – by the Fenton reaction (5), resulting in an increase in oxidative stress and damage to cellular macromolecules. Oxidative stress is associated with diabetes and with disturbances in iron metabolism. Diabetes alters the availability of redox active Fe2+ either from excessive iron stores or from alterations in the protective mechanisms which normally prevent the release of free iron (6)
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
