Abstract
Background: Goats in India are endangered by various disease outbreaks. A limited number of disease conditions in goats have been investigated with regard to the effect of oxidative stress. Oxidative stress is an active field of research implicated in numerous disease processes including sepsis, enteritis, pneumonia, mastitis, joint diseases etc. The present work was undertaken to study the oxidative stress contributing pathological changes in naturally occurring Peste des petits ruminant virus (PPRV) in goats of Jabalpur region. Methods: A total of 30 positive PPR samples (19 plasma and 11 lung tissues) were processed for oxidative stress assessment by oxidative stress markers malondialdehyde (MDA) and glutathione (GSH). The oxidative stress was revealed among 30 PPR positive goats when compared with 10 healthy animals. Necropsy examination was conducted to observed gross pathology and lung tissues were collected for histopathological examination. Result: Oxidative stress was observed with decreased GSH and increased MDA concentration among PPRV positive goats in plasma and in lung tissues respectively. Nineteen PPR positive goats revealed different degree of clinical signs and were devided into three groups viz group I mild, group II moderate and group III severe. Grossly, eleven positive goat carcasses revealed pneumonic lesions. Microscopically, lung sections revealed broncho-interstitial pneumonia. These findings are suggestive of oxidative stress induces pathological changes and lead to dehydration and death of goats.
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