Oxidation of the acridine by peroxy acids in various organic solvents

Abstract

The rate of oxidation reaction of the acridine with peroxy acids in various organic solvents was studied. It has been found the effective rate constants ( k ) and the activation energy ( E a ) of studied process. The rate of oxidation acridine does not depend on the nature of peroxy acid. Between the parameters of the transition state Δ Н ≠ and Δ Ѕ ≠ is some linear relationship, indicating on the presence of the counteraction effect in our series of experiments. The rate of oxidation and activation energy inflation of solvation peroxy acid and acridine was calculated. The reaction medium affects the rate of oxidation. Correlation equations between the rate constants of the reactions in study and the physicochemical parameters of the solvents were proposed. The correlation equation for effective rate constants and the basic physicochemical parameters of solvents at 318 K has the form: lg k =4,37169+ (14,7818 ±1,9305 ) f ( n ) - (3,4465 ±0,6137) f ( ε ) + + ( 0,0035 ± 0,0005) B - (0,1005 ± 0,0150) E T - ( 0,0488 ± 0.0052 ) V M . N=8; R=0, 9755; S= 0, 0678; F=66,9699. The polarizability, polarization , basicity V M and of solvent have effect on the oxidation process. Correlation equations for effective rate constants for other temperatures are similar. The correlation equation for effective energies ( E a ) of activation and the basic physicochemical parameters of solvents has the form: lgE ак =2,4901+(0,0006 ±0,0001) B - (0,0013 ±0,0002 δ 2 -(0,0058 ±0,0009) V M N=8; R= 0,9984; S=0,0054; F=4909,8110. The basicity, molar volume and Hildebrand's function of solvent have effect on the energy of activation process. The proposed correlation equations relate the parameters of the transition state of the oxidation process and the physic-chemical parameters of solvents. Keywords: acridine, oxidation reaction, peroxy acids, activation energy, correlation equation.