Abstract
Solid lipid nanoparticle is a novel approach for topical drug delivery. As lipids used in preparation of solid lipid nanoparticles (SLN) will also get absorbed in skin layers, enhancing permeation across the biological membranes. For the stability of SLN dispersion, several surfactants were used. Mechanism incorporating for the preparation of SLN also impacts particle size and stability. Since the mechanism of SLN through the biological membrane is still under research as it may follow various skin penetration pathways. This review suggests the various method of preparation, common pathways of skin permeation, lipids and surfactant utilized in the production of SLN.
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