Abstract
Hypertrophic stimuli, such as mechanical stretch, up‐regulate heat shock proteins (HSPs) that are mediated by heat shock transcription factor 1 (HSF1)‐associated stress response in mammalian skeletal muscles. However, a physiological significance of HSF1‐associated stress response in loading‐associated muscle hypertrophy is still unclear. The purpose of this study was to investigate the effects of HSF1‐deficiency on loading‐associated skeletal muscle hypertrophy by using HSF1‐null mice. Functional overloading on left soleus was performed by cutting the distal tendons of gastrocnemius muscles for 4 weeks. Hypertrophy of soleus muscle in HSF1‐null mice was partially depressed. On the other hand, overloading‐related up‐regulation of IL‐6 mRNA was enhanced in HSF1‐null mice. Evidences from this study suggested that HSF1 and HSF1‐associated stress response may play an important role in loading‐induced muscle hypertrophy via the regulation of inflammatory cytokines. This study was supported, in part, by JSPS KAKENHI Grants Numbers 22240071, 24650411, 24650407 and the Promotion and Mutual Aid Corporation for Private Schools of Japan.
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