Abstract
Objective To detect the expression of Rho GDP dissociation inhibitor 2 (RhoGDI2) and analyze the function of RhoGDI2 in the colorectal cancer. To discuss the role of RhoGDI2 in the developmetal process of colorectal cancer. Methods Immunohistochemistry was used to detect RhoGDI2 protein in 153 cases of colorectal cancer and adjacent tissue specimens. Results Specimens from 153 cases of colorectal cancer were selected from Affiliated Hospital of Shandong Academy of Medical Sciences between July 2012 and July 2014. RhoGDI2 was expressed mainly in colorectal cancer, mainly in the cytoplasm. The positive rate of RhoGDI2 protien expression was significantly higher in cancer tissue than in normal colorectal tissue (57.5 % vs 0.00%). RhoGDI2 expression in colorectal cancer tissue with the low differentiation group was significantly higher than in the high and moderate differentiation group. The expression of RhoGDI2 protein in colorectal cancer was significantly correlated with tumor size (χ2=4.293, P 0.05)、age ( 0.05). Conclusions RhoGDI2 expression was positively correlated with the invasion and metastasis of colorectal cancer, and RhoGDI2 may play an important role in the occurrence and development of colorectal cancer. Key words: Colorectal neoplasms; Neoplasm metastasis; Invasion; RhoGDI2
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