Abstract
To explore the related factors on the clinical pregnancy outcome in intrauterine insemination, a retrospective study was conducted on the clinical data of 580 cycles for 301 infertile couples who were treated with intrauterine insemination. The female age, male age, duration of infertility, treatment protocols, endometrial thickness and sperm parameters were compared between pregnant group and non-pregnant group. The results showed that there were statistical differences in female age, duration of infertility and endometrial thickness between the two groups. The pregnancy rate was 19.34% in Group A (female age ≤ 30 y) compared with 10.91% in Group B (female age > 30 y). The pregnancy rate was 18.44% when the duration of infertility ≤ 2 years, which was higher than another group 10.73% when the duration of infertility > 2 years. Group analysis according to endometrial thickness (Group1: < 8 mm; Group 2: ≥ 8 mm and ≤ 12 mm; Group 3: > 12 mm) demonstrated significant differences in clinical pregnancy rate (7.41%, 18.00% and 11.48% respectively). For those infertile female without ovulation failure, the higher clinical pregnancy rates were observed in patients undergoing intrauterine insemination in natural cycle 16.12% when compared with the patients in ovarian stimulated cycles 10.48%. Thus, we demonstrate that the pregnancy rate is related with female age, duration of infertility and endometrial thickness. The ovarian stimulated cycle couldn’t improve the pregnancy outcome for those women without ovulation disorder in intrauterine insemination.
Highlights
Intrauterine insemination (IUI) is the first-line approach for infertile couples in the assisted reproductive treatment (ART) procedures, which is used widely for a broad range of indications in the reproductive medicine
31 couples performed more than four IUI cycles
IUI is the first-line treatment during ART procedure [9], which makes sperm bypass the cervical-barrier to increase the number of sperm surrounding the egg
Summary
Intrauterine insemination (IUI) is the first-line approach for infertile couples in the assisted reproductive treatment (ART) procedures, which is used widely for a broad range of indications in the reproductive medicine. The pregnancy rate per cycle with IUI is otherwise compared with IVF/ICSI [2, 4]. The sperm preparation techniques have been improved much in recent decades [5, 6], the clinical pregnancy rate with IUI remains unchanged [7, 8]. According to the reports from a large number of reproductive centers, the clinical pregnancy rate with IUI per cycle is between 11.4% and 12.6% [1]. Data from 580 cycles for 301 infertile couples in our center was analyzed to define which the following factors, including female age, male age, duration of infertility, treatment protocol, endometrial www.impactjournals.com/oncotarget thickness, sperm parameters and treatment cycles, contribute to the positive clinical pregnancy outcomes
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