Abstract
Ovarian hilar cell tumor with coexistent polycystic ovaries and diffuse myometrial hypertrophy have been found in a 34-year-old virilized woman with a markedly elevated plasma level of testosterone. Following total abdominal hysterectomy and bilateral salpingo-oophorectomy, the plasma level of testosterone returned to normal. Light microscopic examination of the tumor showed polygonal cells with abundant eosinophilic cytoplasm. A few cells contained intracytoplasmic crystals of Reinke. Electron microscopy revealed abundant endoplasmic reticulum forming vesicles and whorls and numerous pleomorphic mitochondria with peripherally located tubular cristae: ultrastructural features of cells engaged in synthesis of hormones. Immunoperoxidase studies of formalin-fixed, paraffin-embedded tissue demonstrated the presence of testosterone within ovarian tumor, ovarian stroma, and granulosa cells lining the follicular cysts.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
