Abstract
Ototoxicity of ethacrynic acid in concentrations of 10, 30, and 50 mg/kg was investigated by measuring the endocochlear potentials (EP), cochlear microphonics (CM), whole nerve action potentials (AP), and summation potentials (SP). Results indicated an ototoxic effect of ethacrynic acid in concentrations of 30 and 50 mg/kg, and in concentrations of 10 mg/kg if the doses were repeated in two hours. Ethacrynic acid inhibits active ion transport in the tissues of the cochlear duct. This is manifested by a drop in EP, CM, and AP. The strongest effect of ethacrynic acid was observed in the hair cells, with the drop in CM remaining after four hours with no tendency to recover. The hair cells may have a different type of metabolism from the other structures in the cochlear duct. Also, the SP appears to be comprised of two distinct parts, positive and negative, which may be generated by different sources. The negative SP is dependent on active ion transport and is altered by high dosages of ethacrynic acid.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Archives of Otolaryngology - Head and Neck Surgery
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
