Abstract
The toxic effect of long-term administration of cadmium on bone was studied histochemically and biochemically in rats fed cadmium at dietary concentrations of 10, 50, or 100 ppm. After 19 months on these diets the rats were sacrificed. In the femur of rats fed a cadmium-supplemented diet (groups 2–4), many areas of cortical osseous tissues were unstained with hematoxylin and eosin, but stained blue with alcian-blue or azan-Mallory methods. This implies the existence of osteoid tissue containing glycoaminoglycans and collagenous tissues. This histological change increased in a dose-dependent fashion with the amount of dietary cadmium. Calmium concentrations in femurs decreased in proportion to the increase in the amount of administered cadmium.
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