Abstract
Magnesium (Mg) alloys have a wide range of biomaterial applications, but their lack of biocompatibility and osteoinduction property impedes osteointegration. In order to enhance the bioactivity of Mg alloy, a composite coating of fluorinated hydroxyapatite (FHA) and tantalum (Ta) was first developed on the surface of the alloy through thermal synthesis and magnetron sputtering technologies in this study. The samples were characterized by scanning electron microscopy (SEM), atomic force microscopy (AFM), energy dispersive spectroscopy (EDS) mapping, X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and water contact angle measurement (WCA), which characterized the surface alternation and confirmed the deposition of the target FHA/Ta coating. The results of cell morphology showed that the MC3T3-E1 cells on the surface of Mg/FHA/Ta samples had the largest spreading area and lamellipodia. Moreover, the FHA coating endowed the surface with superior cell viability and osteogenic properties, while Ta coating played a more important role in osteogenic differentiation. Therefore, the combination of FHA and Ta coatings could synergistically promote biological functions, thus providing a novel strategy for implant design.
Highlights
Numerous bone repair materials have been developed to replace autograft bones and are commercially available as bone substitutes
Mg/Ta7 revealed superior cell viability compared to Mg (ODs: 0.241 ± 0.048, p < 0.05), the cell viability was decreased as compared with Mg/Ta5
The results indicated that the Ta coating might be too thin to be detected, or the magnetron sputtering process did not generate the crystal phase of Ta (Wang et al, 2020)
Summary
Numerous bone repair materials have been developed to replace autograft bones and are commercially available as bone substitutes. The currently available biodegradable implants usually comprise of bio-ceramics and resorbable polymers, with the poor mechanical strength of the bioceramics and polymers compromising their application (Upadhyay et al, 2020). Metallic materials are commonly used for repair or replacement of damaged bone tissue. Those currently widely employed in orthopedics include titanium alloys because of their good mechanical properties and cytocompatibility. The inert materials often need to be removed via invasive secondary surgeries once the bone has healed completely. Magnesium (Mg) and its alloys have attracted significant research attention as potential metallic implants and GBRs (guide osteogenesis membranes) due to exceptionally light weight, in vivo degradation, and excellent mechanical
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
