Abstract
We cytogenetically investigated six osteoid osteomas, one osteoblastoma and one aggressive osteoblastoma, and observed clonal structural changes in one osteoid osteoma and in the aggressive osteoblastoma. Clonal chromosome changes had not been reported previously in osteoid osteoma, whereas the only reported chromosome change in osteoblastoma was different from the one presented here.
Highlights
MethodsEight bone-forming tumoral lesions were investigated as part of an ongoing study on the cytogenetic characterization of bone tumours
The difficulty in separating osteoblastoma from osteosarcoma has led to the concepts of 'aggressive' and 'malignant' osteoblastoma (Fechner and Mills. 1992: Della Rocca and Huvos. 1996)
We report the finding of clonal chromosome aberrations in a locally aggressive osteoblastoma. and present the first abnormal karyotype ever found in osteoid osteoma
Summary
Eight bone-forming tumoral lesions were investigated as part of an ongoing study on the cytogenetic characterization of bone tumours. The clinical history of the two cases (nos 2 and 8) showina clonal chromosomal abnormalities is presented in detail below,. Rounded bone lesion on the right talar neck 3 years A. Fgure 1 Two-dime ren in the sagittal of the preoperatrve CT scan of the right ankle showing the hyperostotic-appearing zsreoocnmuereroecfnatlpcroiefsviticeoaotuiisdonsosusrotgreeoorsymsaiafni(dcc.aatsaiebononsvo.eina2t)nhde cbeenltroew. This region, suggesting a tyc zone a locally with _. CT image shows the large recurrent tumour with hyperdense and areas invading the sacrum 3 months after iliac bone resection and despite intensive chemotherapy ;4-. On clinical examination the onlv significant finding was a deep hard lump of 3 x 3 cm in this area
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