Abstract
Oscillations of H + secretion rate, active net charge transport measured as short-circuit current and transmucosal electric potential difference with a regular frequency of one period in 45 min appeared spontaneously in the isolated frog gastric mucosa. Similar oscillations were triggered by the addition of histamine at 45-min intervals. The spontaneous oscillations and the continuatino of histamine triggered oscillations after cessation of histamine administration indicates that there was a component of slow inherent rhytmicity in the mucosa. No oscillations were obtained when a small transmucosal gradient of Cl − was used. With the histamine-triggered oscillations the H + secretion rate was always 180° out of phase with the short-circuit current and the potential difference. This supports the hypothesis of an electrogenic mechanism for active transport of H + in the mucosa that can function at least partially independently of that for Cl −.
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