Abstract
Fluorescent 5-coordinate organotin-flavone complexes of 3-hydroxyflavone (Hof) and 3,5,7,2′,4′,-pentahydroxyflavone (morin) are good inhibitors of mitochondrial F 1F 0ATPase but do not inhibit F 1-ATPase and they have been examined as possible fluorescent probes of F 1F 0ATPase. R 2SnX (morin) complexes exhibit low fluorescence enhancement on binding to mitochondrial membranes with no displacement by equimolar tributyltin. In contrast R 2SnX (of) complexes exhibit high fluorescence enhancement whose extent is variable and is displacable by equimolar tributyltin. Fluorescence enhancement by R 2SnX (of) complexes correlates with the ATPase I 50 values. Dialkyltin-3-hydroxy flavone, R 2SnX(of), complexes act as a new class of fluorescent probes which titrate the F 0 segment of F 1F 0ATPase.
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