Abstract
Abstract Interaction of methylene aminoacetaldehyde dimethylacetal and dimethylphosphite produces the phosphonomethyl-substituted aminoacetaldehyde acetal 1. Using bis(trimethylsilyl)phosphite in this reaction and hydrolyzing the reaction mixture with alcohol gives the stable crystalline N-dihydroxyphosphonylmethyl-aminoacetaldehyde acetals 3a and 3b. Complete hydrolysis of 3a and 3b with HCl produces N-dihydroxyphosphonylmethyl-aminoacetaldehyde hydrate, 4, as shown by 13C-NMR spectroscopy. None of the compounds exhibited biological activity.
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