Abstract

The physiological roles of the the lateral hypothalamic area (LHA) have been shown historically by lesioning and complementary electrical stimulation studies. Animals with lesions of the LHA exhibit hypophagia and an increased metabolic rate, whereas electrical stimulation studies of the LHA showed that acute stimulation causes hyperphagia and that chronic stimulation can cause obesity. Therefore, it has long been thought that the LHA is a feeding center and an important region for the regulation of body weight homeostasis (1, 2, 3). Because orexin/hypocretin neurons are localized exclusively in the LHA, orexins have been thought to participate in the regulation of feeding behavior. Many studies have now shown the physiological importance of orexins in the regulation of feeding behavior. This chapter explores the roles of orexin in the regulation of feeding behavior and energy homeostasis.

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