Orchestrating Binding Interactions and the Emergence of Avidity Driven Therapeutics.

Abstract

ADVERTISEMENT RETURN TO ARTICLES ASAPPREVFirst ReactionsNEXTOrchestrating Binding Interactions and the Emergence of Avidity Driven TherapeuticsMultiple carbohydrate ligands are arranged within a single therapeutic agent to achieve significant increases in apparent binding affinity or “avidity” for a target lectin receptor.Eden KapcanEden KapcanDepartment of Medicine, Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario L8S 4L8, CanadaMore by Eden Kapcan, Benjamin P. M. LakeBenjamin P. M. LakeDepartment of Medicine, Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario L8S 4L8, CanadaMore by Benjamin P. M. Lake, and Anthony F. Rullo​Anthony F. RulloDepartment of Medicine, Department of Chemistry and Chemical Biology, McMaster University, Hamilton, Ontario L8S 4L8, CanadaEmail: [email protected]More by Anthony F. Rullohttps://orcid.org/0000-0002-5868-3583Cite this: ACS Cent. Sci. 2023, XXXX, XXX, XXX-XXXPublication Date (Web):March 16, 2023Publication History Published online16 March 2023https://doi.org/10.1021/acscentsci.3c00242Published 2023 by American Chemical SocietyRIGHTS & PERMISSIONSACS AuthorChoiceCC: Creative CommonsBY: Credit must be given to the creatorArticle Views711Altmetric-Citations-LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit PDF (916 KB) Get e-Alerts Get e-Alerts