Abstract
ABSTRACT Objective: To enhance recognition of ocular inflammation as a rare side effect of zoledronic acid. Methods: A case report of bisphosphonate-induced orbital inflammation with permanent visual deterioration and pertinent literature review. Results: A 66-year-old man with newly diagnosed osteoporosis and concomitant hypertension, hyperlipidemia, and gastroesophageal reflux disease was treated with intravenous zoledronic acid. He developed acute anterior uveitis on day 4 after treatment, manifested by orbital erythema, swelling, and decreased visual acuity. His symptoms resolved after a course of systemic glucocorticoid. However, he developed blurred vision 3 months after treatment with zoledronic acid and was diagnosed with cystoid macular edema and wrinkling retinopathy, thought to be related to prior history of uveitis. He underwent intravitreal steroid injection, with a partial response 6 months after use of zoledronic acid, later followed by retinal surgery. At 24 months after zoledronic acid in...
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