Abstract
Objectives The exposure of mucosal surfaces to HIV-1 stimulates systemic and mucosal immune responses even in the absence of an established infection. We have investigated whether oral exposure to HIV-1 is sufficient to mount an anti-HIV-1 response in exposed uninfected (EU) individuals of discordant couples in the Men who have sex with men group (MSM). Further we have evaluated if this response correlates to the level of exposure measured by the HIV-seropositive partners virus load.
Highlights
Klara Hasselrot*Address: Karolinska University Hospital, Stockholm, Sweden * Corresponding author from 2006 International Meeting of The Institute of Human Virology Baltimore, USA
We have investigated whether oral exposure to HIV-1 is sufficient to mount an anti-HIV-1 response in exposed uninfected (EU) individuals of discordant couples in the Men who have sex with men group (MSM)
Unprotected oral sex in discordant MSM couples is sufficient to mount an anti-HIV response in EU individuals, both in the mucosal compartment as well as systemically. This neutralizing capacity within the EU group correlates with the level of exposure measured by the virus load in the HIV-positive partner
Summary
Address: Karolinska University Hospital, Stockholm, Sweden * Corresponding author from 2006 International Meeting of The Institute of Human Virology Baltimore, USA. 17–21 November, 2006 Published: 21 December 2006 Retrovirology 2006, 3(Suppl 1):P23 doi:10.1186/1742-4690-3-S1-P23. 2006 International Meeting of The Institute of Human Virology Meeting abstracts. A single PDF containing all abstracts in this Supplement is available here http://www.biomedcentral.com/content/pdf/1742-4690-3-S1-info.pdf
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