Abstract
Prevotella is recognized as one of the core anaerobic genera in the oral microbiome. In addition, members of this genus belong to microbial communities of the gastrointestinal and respiratory tracts. Several novel Prevotella species, most of them of oral origin, have been described, but limited knowledge is still available of their clinical relevance. Prevotella melaninogenica is among the anaerobic commensals on oral mucosae from early months of life onward, and other early colonizing Prevotella species in the oral cavity include Prevotella nigrescens and Prevotella pallens. Oral Prevotella species get constant access to the gastrointestinal tract via saliva swallowing and to lower airways via microaspiration. At these extra-oral sites, they play a role as commensals but also as potentially harmful agents on mucosal surfaces. The aim of this narrative review is to give an updated overview on the involvement of oral Prevotella species in gastrointestinal and respiratory health and disease.
Highlights
Anaerobic bacteria constitute a significant part of oral microbial communities
Biopsy specimens from the distal esophagus of four healthy individuals were examined with 16S rDNA sequencing-based techniques, and the results showed Bacteroidetes as the second most common phylum and Prevotella as the second most common genus after Streptococcus
Changes in abundance were seen for several Prevotella species, such as P. denticola, P. oris, P. jejuni, P. intermedia, P. melaninogenica, P. fusca, and P. scopos, which were among the 37 species distinctive for the healthy and diseased individuals, and most of them separated the symptomatic COVID-19 and non-COVID groups from each other (Xiong et al, 2021)
Summary
Anaerobic bacteria constitute a significant part of oral microbial communities. In the oral cavity, Bacteroidetes is one of the major phyla and Prevotella its largest genus (Dewhirst et al, 2010). Oral Prevotella Species in Health and Disease composition of microbial communities of the lower respiratory tract (Bassis et al, 2015; Dickson et al, 2016).
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