Abstract
Background The induction of a potent humoral and cellular immune response both in the peripheral and mucosal tissues is important for the development of an effective HIV vaccine. The present study explores the ability of a Lactococcus lactis (L. lactis), a probiotic organism, based oral vaccine to elicit HIV-specific immune responses in the mucosal and systemic compartments of mice and rhesus monkeys.
Highlights
The induction of a potent humoral and cellular immune response both in the peripheral and mucosal tissues is important for the development of an effective HIV vaccine
The present study explores the ability of a Lactococcus lactis (L. lactis), a probiotic organism, based oral vaccine to elicit HIV-specific immune responses in the mucosal and systemic compartments of mice and rhesus monkeys
To express the HIV-1, Gag (p24) on the tip of the pilus, we made a fusion construct of Gag and Cpa protein of the type-3 pilus found in Streptococcus pyogenes and expressed in L. lactis
Summary
The induction of a potent humoral and cellular immune response both in the peripheral and mucosal tissues is important for the development of an effective HIV vaccine. The present study explores the ability of a Lactococcus lactis (L. lactis), a probiotic organism, based oral vaccine to elicit HIV-specific immune responses in the mucosal and systemic compartments of mice and rhesus monkeys
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