Abstract
Treating with ion exchange resin has chemically modified metformin hydrochloride to form an oral controlled release beads using ion-exchange resin sorption method. A strong cation exchange resin Amberlite IR 120 was utilized for the sorption of the drug and the drug resinates was evaluated for various physical and chemical parameters. The drug content and percentage drug release were determined spectrophotometrically at 233 nm. About 43% of drug was loaded in 4.5 h and in-vitro dissolution study showed 84% of drug release in 8 h. The drug-resinate complex was microencapsulated with a polymer Eudragit RS 100 to further retard the release characteristics. Further, the drug-resinate complex and microencapsulated drug resinate were suspended in a palatable aqueous suspension base and were evaluated for controlled release characteristic.
Highlights
Metformin HCl was procured as a gift sample from Zydus Research Centre, Ahmedabad as gift sample and used as such
Metformin was dissolved in 100 ml demineralised water and Amberlite IR 120 was added in the 1:1 proportion
The process for preparing drug resinate was optimized with respect to methodology, drug resin proportion and time for sorption
Summary
HCl) is used as oral hypoglycaemic drug from the biguanide class and used in the management of type 2 diabetes mellitus[1]. It is known as 2-(N, Ndimethylcarbamimidoyl) guanidine with a molecular weight of 165.62. Major action of metformin HCl lay in increasing glucose transport across the cell membrane in skeletal muscle 2. It is soluble in water but IJBAR (2010) 01(04). Much of the research effort in developing novel drug delivery systems has centred on sustained or controlled release of drug from dosage forms.
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