Abstract
This study was to demonstrate whether loquat leaves protect against 7,12-dimethylbenz[α]anthracene (DMBA)-induced breast cancer in female rats. Rats were fed control diet (NC, DC), ethanol (DE), or water extract of loquat leaves (DW) until sacrifice. At 50 days of age, animals in the DC, DE, and DW groups were given a single intra-gastric dose of DMBA (50 mg/kg) dissolved in corn oil. Both the water and ethanol extracts of loquat leaves decreased the incidence of tumors, with water extract having the higher inhibitory effect. Ethanol extract significantly decreased the multiplicity of tumors. Loquat extracts significantly decreased tumor cell proliferation and the tumor grade based on the degree of tubule formation. These results suggest that both water and ethanol extracts of loquat leaves inhibit the development of breast cancer. Such inhibition may be based on the suppression of initiation and tumor cell proliferation.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
