Abstract
This study aimed to investigate the anti-allergic effects of Lactobacillus plantarum K37 (K37) on airway hyperresponsiveness (AHR) and systemic allergic responses in ovalbumin (OVA)-sensitized and -challenged BALB/c mice. Heat-inactivated K37 (105, 107, and 109 CFU/mouse, day) were orally administered to OVA-sensitized BALB/c mice to investigate their effects on AHR, immunoglobulin (Ig) and cytokine production. The results showed that K37 dose-dependently lowered the serum levels of IgE, OVA-specific IgE and OVA-specific IgG1, ameliorated AHR induced by methacholine and suppressed eosinophil infiltration in bronchoalveolar lavage fluid (BALF). The cytokine production in spleen cells culture and BALF showed that K37 drove the immune responses toward T-helper cell type 1 (Th1) responses, elevated levels of IL-2 and IFN-γ, and reduced of IL-4, IL-5 and IL-13. K37 also improved cell infiltration in lung sections. Our results demonstrated that oral administration of K37 alleviated effectively the allergic responses in vivo. Thus, K37 can be a good source material and a promising candidate for prophylactic and therapeutic treatments of allergic diseases, like asthma.
Highlights
Allergic disorders, such as allergic rhinitis [1], atopic dermatitis [2], food allergies [3], and allergic asthma [4], affect the individual’s life quality and become a medical burden on society
Allergies are related to the T helper cell type 2 (Th2) responses which can be characterized by the production of cytokines, interleukin (IL)-4, -5, -13, the production of total immunoglobulin (Ig) E and antigen-specific Igs (i.e. IgE, IgG1 and IgG2) and the accumulation of eosinophils [5]
This study investigated the effects of orally administered heatinactivated K37 on OVA-induced allergic asthma in BALB/c mice model
Summary
Allergic disorders, such as allergic rhinitis [1], atopic dermatitis [2], food allergies [3], and allergic asthma [4], affect the individual’s life quality and become a medical burden on society. Allergies are related to the T helper cell type 2 (Th2) responses which can be characterized by the production of cytokines, interleukin (IL)-4, -5, -13, the production of total immunoglobulin (Ig) E and antigen-specific Igs (i.e. IgE, IgG1 and IgG2) and the accumulation of eosinophils [5]. Th2 responses can be suppressed by T helper cell type 1 (Th1) cells which secreted interferon (IFN)-c, IgG2a, IL-2, and IL-3 [8]. To regulate the immune responses by suppressing Th2-responses while enhancing Th1responses is expected to be helpful in the treatment of allergy and other Th2-dominant disorders, such as asthma which is a chronic, complex respiratory disease caused by various airway obstructions, airway eosinophil inflammation, and bronchial hyperresponsiveness [9]
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