Abstract
Capsaicin (CP) is the pungent component of chili peppers. We have observed previously that dendritic cells (DCs), a key cell type in immune responses, have the receptor for CP, and engagement of this receptor has powerful immune consequences. As CP can be used as a powerful adjuvant in enhancement of an immune response, we tested its immunomodulatory activity by oral administration in treatment of Type 1 diabetes (T1D) in non‐obese diabetic (NOD) mice. Here we demonstrate that oral administration of CP delays the onset of diabetes in NOD mice in a dose dependent manner and adoptive transfer of splenocytes from CP treated mice can transfer protection in recipient NOD mice. Further, CP administration attenuates OVA specific naïve T cell (OT1) proliferation in pancreatic lymph nodes (PLN) of RIP‐OVA mice. These results reflect the immunological potency of a neurological ligand in modulating cross‐presentation ability of islet DCs in the draining PLNs.
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