Abstract
Oral abstracts of the 22nd International AIDS Conference, 23-27 July 2018, Amsterdam, the Netherlands.
Highlights
A proposed strategy to purge HIV reservoir is to reactivate provirus transcription with latency-reversing agents (LRAs), inducing viral antigen expression and allowing immune-mediated clearance of reservoir cells in the presence of combination antiretroviral therapy
There were no differences by arm (Table 1). 52% of outpatients in the HIVST arm tested for HIV compared to 14% in Optimized PITC (AOR: 6.6 p < 0.001) and 12% in PITC (AOR: 7.6 p < 0.001)
Positivity rates did not differ by arm, HIVST was associated with a higher absolute number of new positives identified compared to Optimized PITC (AOR: 2.9, p = 0.01) and PITC (AOR: 4.1, p = 0.002)
Summary
52% of outpatients in the HIVST arm tested for HIV compared to 14% in Optimized PITC (AOR: 6.6 p < 0.001) and 12% in PITC (AOR: 7.6 p < 0.001). For HIVST, 60% of outpatients in need of testing (defined as tested >12 months ago and never tested HIV-positive) were tested compared to 18% in Optimized PITC and 16% in PITC. Positivity rates did not differ by arm, HIVST was associated with a higher absolute number of new positives identified compared to Optimized PITC (AOR: 2.9, p = 0.01) and PITC (AOR: 4.1, p = 0.002). Participants who were tested by HIVST were more likely to want to test again using the same method and more likely to recommend testing to others compared to those tested by Optimized PITC or PITC. No adverse events were reported in the HIVST arm.
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