Optimizing the management of tricuspid regurgitation: an update on current treatment strategies and perspectives

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ABSTRACT Introduction Tricuspid regurgitation (TR) is a prevalent condition and is independently associated with high morbidity and mortality rates. Despite its prognostic impact, TR remains undertreated, with patients often referred at late stages when medical therapy is ineffective and surgical intervention high risk. Emerging transcatheter therapies offer a promising alternative for safer and effective management of this elderly patient population with numerous comorbidities. Areas covered This review highlights recent advances in treatment strategies and future directions for addressing significant TR. The literature search was conducted across the PubMed, Embase, Scopus, and Google Scholar databases. A structured search strategy was developed using ‘tricuspid regurgitation’ and ‘management’ or ‘treatment’ or ‘therapy’ and ‘surgery’ or ‘tricuspid valve repair’ or ‘tricuspid valve replacement’ or ‘transcatheter tricuspid intervention’ as MeSH terms and keywords. Selected articles from 2017 to present were critically analyzed for strengths, limitations, and gaps in evidence. Expert opinion Enhancing disease awareness, the involvement of multidisciplinary Heart Team and intervening earlier are critical priorities for TR therapies to prevent treatment futility. Improved device designs, more performant imaging techniques, and dedicated research endpoints will help optimizing the management of TR.