Optimizing sorbitol double dehydration: A Box-Behnken design approach with commercial sulfonic acid resin

Abstract

In this study, double dehydration of sorbitol into isosorbide using commercial sulfonic acid resin as a catalyst was carried out under vacuum conditions generated by water ejection. To improve the efficiency and selectivity of the process, optimum reaction conditions prescribed by temperature, catalyst loading, and reaction time were investigated using the Box-Behnken design (BBD) together with Response Surface Methodology (RSM). The results showed that using the water ejection system could increase reaction activity. Statistically, all the reaction parameters were found to significantly affect the double dehydration reaction response, including sorbitol conversion, 1,4-sorbitant yield, and isosorbide yield. Furthermore, accurate predictive equations for all the reaction responses displayed R2 > 95 %, with no significant errors observed. The optimized conditions resulted in the complete conversion of sorbitol with 6.42 % 1,4-sorbitant yield and 67.55 % isosorbide yield. The equations yielded predicted values of the responses with minor variances being lower than 1 % when compared with the experimental values. However, the efficiency of the catalyst decreased steadily over recycling cycle due to reduced active sites and textural properties, likely caused by structural collapse and by-product accumulation. This work contributes to biomass valorization by optimizing the effective process for the production of isosorbide via commercial catalysts under vacuum conditions.