Abstract

Overuse of antibiotics has reduced effective medications, requiring research to combat drug-resistant bacteria and superbugs. This work explores the synthesis of a p-n junction ZnO/Ag2O composite for antibacterial photodynamic therapy. The as-prepared sample was thoroughly characterized using optical and structural analyses, scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy. Our ZnO/Ag2O composite outperformed pristine ZnO in deactivating bacterial while also demonstrating high biocompatibility with normal cells. In silico molecular docking demonstrates that ZnO/Ag2O composite has a strong binding affinity for bacteria proteins, which exhibits great antibacterial activity against E. coli and S. aureus.

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