Abstract
Enriched [18O]-water is the target material for [18F]-fluoride production. Due to its high price and scarce availability, an increased interest and necessity has arisen to recycle the used water, in order to use it multiple times as a target material for [18F]-fluoride production. This paper presents an efficient treatment and reprocessing procedure giving rise to high chemical quality [18O]-water, thereby maintaining its enrichment grade. The reprocessing is subdivided into two main steps. In the first step, the [18F]-FDG (fluorodeoxyglucose) synthesis preparation was modified to preserve the enrichment grade. Anhydrous acetonitrile is used to dry tubing systems and cartridges in the synthesis module. Applying this procedure, the loss in the enrichment throughout the reprocessing is <1%. The second step involves a fractional distillation in which the major part of the [18O]-water was recycled. Impurities such as solvents, ions, and radioactive nuclides were almost completely separated. Due to the modified synthesis preparation using acetonitrile, the first distillation fraction contains a larger amount of an azeotropic [18O]-water/acetonitrile mixture. This fraction is not further distillable. Contents of the remaining [18O]-water were separated from the azeotropic mixture by using a molecular sieve desiccant. This process represents a fast, easy, and inexpensive method for reprocessing used [18O]-water into new [18O]-water quality for further application.
Highlights
The [18 O]-water recovered from the synthesis of [18 F]-based radiopharmaceuticals could in principle be reused for further irradiation
The recycled [18 O]-water has to be of high chemical quality, and of the highest possible enrichment grade
A fractional synthesis module ensures preparation ensures the of maintenance of the enrichment of the distillation was performed for the purification of the
Summary
The [18 O]-water recovered from the synthesis of [18 F]-based radiopharmaceuticals could in principle be reused for further irradiation. The recycled [18 O]-water has to be of high chemical quality, and of the highest possible enrichment grade. The recycling processes using condensation and/or UV-irradiation did not lead to good [18 O]-water quality, sufficient quantity, or a stable enrichment grade [6,7,8]. Most of the end users collect the irradiated [18 O]-water samples and return them to the manufacturers for recycling. Instruments 2018, 2, 12 recycle >90% of the [18O]-water, while maintaining the enrichment grade with the prescribed method. [18O]-water quality radiation, needs to the possess a high quality chemical quality, enrichment grade with the prescribed. Thereby attaining the release possess a high chemical quality,specifications thereby attaining
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