Optimized radioiodine therapy for Graves?? disease: Two MIRD-based models for the computation of patient-specific therapeutic 131I activity

Abstract

(131)I therapy is increasingly used for Graves' hyperthyroidism. Debate remains about the best method for calculating the activity to administer, as well as about the potential benefit of such computed activity. Several arguments plead, nevertheless, in favour of a personalized computation, such as inter-individual variations of thyroid volume and biokinetics. A MIRD-based dosimetric approach, with an additional extension that takes into account the variation of thyroid mass during the treatment, has been developed. This approach includes the benefits of a personalized determination of biokinetics. Results were compared with those of six methods widely used in routine practice. Forty-one patients were enrolled (34 women, seven men; mean age +/-SD: 48.11 +/- 6.4 years). (131)I uptakes were measured at 4, 24 and 96 h (36.2 +/- 14.6%, 42.8 +/- 9.7% and 27.6 +/- 6.8%, respectively), following administration of the tracer. The kinetics of iodine in the thyroid were evaluated using a two-compartment model (effective half-life of 5.1 +/- 1.6 days). Computations of activities to deliver the doses prescribed by the physician were done with the eight formalisms. There was no statistical difference between results of the two MIRD-based formalisms (227 +/- 148 MBq and 213 +/- 124 MBq), which were also not significantly different from those obtained with the majority of the other methods (from 128 +/- 95 MBq to 275 +/- 223 MBq). However, a large intra-individual difference up to a factor of 2 between two given methods was found. The formalism developed appears to be a good compromise between all the common formalisms already used in many institutions. Furthermore, it allows the exposures of target volumes and non-target volumes to be planned individually and practical individual radiation protection recommendations to be implemented.