Abstract
In this work, we have established an improved handheld full-field optical coherence tomography (FFOCT) system based on the tandem structure of Michelson interferometer and Fizeau interferometer. We have analyzed the influence of wave aberrations of the handheld FFOCT as a function of orientation deviation of mirror M2 on the system point spread function (PSF) by using the nodal aberration theory. It is found that the range of the orientation deviation of mirror M2 must be less than 0.1° to generate stable FFOCT images. The effect of wave aberrations of defocus as a result of the refractive index difference on the system PSF has also been calculated, the measuring depth in the case of the sample with refractive index of 1.5 and the propagation medium is air (n = 1) should be less than 20 μm. Theoretical analyses have been demonstrated by the experimental results of aluminum powder, onion and porcine myocardium. By comparing the defocused FFOCT images of aluminum powder with defocused FFOCT images of onion and porcine myocardium, it can be concluded that reducing the refractive index difference between the medium and sample can increase the imaging depth of handheld FFOCT system.
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