Abstract
Zingiber cassumunar Roxb contains active compounds such as cassumumin AC, cassummarin AC, phenylbutanoid, and (E) -4- (3,4-dimethoxyphenyl) but-3-en-1-ol which has activities as anti-inflammatory, antioxidant and anti-allergenic agents so that they are potentially used as anti-allergies. Zingiber cassumunar Roxb is made into tablet because it has several advantages, which are easy to consume, practical, the right amount, cover the bitter taste and the distinctive smell and its stability is maintained in storage. This study aims to produce Zingiber cassumunar Roxb tablets that have good physical properties by using PVP as a binder. Zingiber cassumunar Roxb extract was made by maceration using 70% ethanol solvent, the tablet was formulated using wet granulation method. Zingiber cassumunar Roxb ethanol extract tablet was formulated in 3 formulas with variations in the PVP FI content of 1%, FII 2.75%, and FIII 4.5%. The resulting granules were tested for physical properties including moisture test, particle size distribution, flow time, stationary angle, bulk density, and compressibility, while the tablets produced were tested for physical properties including organoleptic test, uniformity of size, uniformity of weight, friability, and disintegration time. The results showed that the optimum concentration obtained was at FIII with 4.5% PVP concentration that complied the organoleptic test requirements, uniformity of size, weight uniformity, and fragility of tablets.
Highlights
Alergi merupakan reaksi hipersensitivitas yang diakibatkan oleh induksi imunoglobulin E (IgE) yang spesifik terhadap alergen tertentu yang akan berikatan dengan sel mast atau basofil
Preparation and quality control Zingiber cassumunar Roxb extract with high-yieded anti-inflammatory active compounds
Phagocytosis Effectivity Test of Phenylbutenoid Compounds Isolated From Bangle (Zingiber cassumunar Roxb) Rhizome
Summary
Alergi merupakan reaksi hipersensitivitas yang diakibatkan oleh induksi imunoglobulin E (IgE) yang spesifik terhadap alergen tertentu yang akan berikatan dengan sel mast atau basofil. Menurut Penelitian Supinya and Sanna (2007), senyawa aktif rimpang bangle yaitu (E)-4(3,4-dimethoxyphenyl) but-3-en-1-ol (Komponen D) dengan nilai IC50 = 20,2 μg/mL dikembangkan sebagai agen antialergi. Kandungan zat aktif rimpang bangle yaitu(E)-4-(3,4-dimethoxyphenyl) but-3-en-1-ol (Komponen D) merupakan senyawa yang tahan terhadap panas dengan titik didih 140142°C dan suhu degradasi 181,87 °C berdasarkan sifat senyawa tersebut maka tablet dapat dibuat dengan metode granulasi basah dengan suhu 4060 °C.Metode granulasi basah digunakan untuk memperbaiki sifat alir dan kompaktibilitas bahan sehingga menjadi lebih mudah saat dibuat menjadi tablet (Banker dan Anderson, 1986). Menurut penelitian Widya dkk (2010), Penggunaan PVP sebagai bahan pengikat menghasilkan tablet yang tidak keras, waktu disintegrasinya cepat sehingga cepat terdisolusi dalam cairan tubuh, terabsorpsi, setelah itu terdistribusi ke seluruh tubuh dan sirkulasi sistemik. Untuk itu perlu dilakukan optimasi konsentrasi PVP etanol 70% rimpang bangle
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
