Abstract
Calculations, analytical solutions, and simulations were used to investigate the trade-off of echo spacing and receiver bandwidth for the characterization of bi-exponential transverse relaxation using a multi-echo imaging pulse sequence. The Cramer–Rao lower bound of the standard deviation of the four parameters of a two-pool model was computed for a wide range of component T 2 values and echo spacing. The results demonstrate that optimal echo spacing ( TE opt) is not generally the minimal available given other pulse sequence constraints. The TE opt increases with increasing value of the short T 2 time constant and decreases as the ratio of the long and short time constant decreases. A simple model of TE opt as a function of the two T 2 time constants and four empirically derived scalars is presented.
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