Abstract
This letter reports an approach for cell contraction force mapping by utilizing optical moiré effect. We cultured living cells on patterned polymer substrates and studied the diffraction moiré patterns. We found that the flexible moiré patterns generated on the periodic substrates are capable of mapping cell contraction force evolution in whole field. We demonstrated one- and two-dimensional force mappings in vascular cells. Due to moiré magnification, this imaging approach can provide a versatile visual tool for mapping the cell-substrate interactions in living cells.
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