Abstract
ObjectiveTo evaluate the retinal perfusion using optical coherence tomography (OCT) angiography in eyes with good visual acuity recovery after treatment for optic neuritis (ON).MethodsSeven eyes of seven patients with good visual acuity recovery after treatment for monocular ON and seven eyes of each fellow eye used as controls were studied. Retinal perfusion around the disc and at the macula was evaluated using OCT angiography. The retinal nerve fiber layer thickness was measured around the disc. The ganglion cell layer complex thickness or the ganglion cell layer plus the inner plexiform layer thickness were measured at the macula.ResultsThe retinal perfusions in all eyes with ON decreased around the disc and at the macula compared with those of the fellow eyes, as shown by OCT angiography (disc, P = 0.003; macula, P = 0.001). The retinal thicknesses in all eyes with ON also decreased around the disc and at the macula compared with those of the fellow eyes (disc, P < 0.001; macula, P = 0.003).ConclusionsOptic neuritis may cause not only retinal structural damage but also decreased retinal perfusion, even after the visual acuity recovered well after treatment.
Highlights
Optic neuritis (ON) is an inflammation of the optic nerve that can be subclassified into various types, including multiple sclerosis (MS)-associated ON, neuromyelitis optica-associated ON, PLOS ONE | DOI:10.1371/journal.pone.0172168 February 13, 2017optical coherence tomography (OCT) angiography in optic neuritisCompany: Consultant, Lecture Fee, Bayer: Consultant, Lecture Fee, Shionogi & CO.: Consultant, Lecture Fee, Pfizer Japan: Consultant, Sanwa Kagaku Institute: Consultant, Carl Zeiss Japan: Lecture Fee, Otsuka Pharmaceutical Company: Lecture Fee, MSD: Lecture, and Kowa Pharmaceutical Company: Lecture Fee
The retinal perfusions in all eyes with ON decreased around the disc and at the macula compared with those of the fellow eyes, as shown by OCT angiography
The retinal thicknesses in all eyes with ON decreased around the disc and at the macula compared with those of the fellow eyes
Summary
To evaluate the retinal perfusion using optical coherence tomography (OCT) angiography in eyes with good visual acuity recovery after treatment for optic neuritis (ON)
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