Abstract
The differential melting profiles of mitochondrial and cytoplasmic ribosomal RNA from the fungus, Aspergillus nidulans were examined. Both rRNAs presented a biphasic melting profile. However, mitochondrial rRNA differed from its cytoplasmic counterpart in the relative proportions and temperature ranges of the various melting phases. Differences were also found between the melting patterns of the heavy and light mitochondrial rRNA components. Thermal denaturation of formaldehyde-treated rRNA showed that mitochondrial rRNA has a partially ordered structure in solution which is stabilized by base pairing in helical regions as well as by base stacking. These results indicate that the forces which contribute to the ordered structure of mitochondrial rRNA resemble those operative in other ribosomal RNAs. In the absolute conformation, however, the unique nature of mitochondrial rRNA becomes apparent.
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