Abstract
In neurons, voltage-gated potassium KCNQ channels (KCNQ2-5) mediate the M-current, one of the major potassium currents throughout the central and peripheral nervous systems. KCNQ channels regulate the resting membrane potential, shape action potentials, and impede repetitive neuronal firing. Inherited mutations in KCNQ2 channel have been linked to the onset of epileptic encephalopathy and other neurodevelopmental disorders. KCNQ2 channels have six transmembrane segments (S1-S6) that form functional tetramers.
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