OP9 Predictive value of CD24 and CD44 for response to neoadjuvant chemotherapy and prognosis in patients with primary breast cancer

Abstract

lung cancer (NSCLC), to stratify potential differences in long-term survival outcomes. Methods: We established a multi-institutional registry for 4138 patients with NSCLC who underwent lobectomy between January, 2000, and December, 2007, from eight institutions in China. Age, gender, histological type, and tumour staging, based on the latest TNM classification, were entered into a non-parsimonious multivariable logistic-regression model. The predicted probability derived from the logistic equation was used as the propensity score for each individual. Based on similar propensity scores, we matched 1356 of the 1584 patients who underwent VATS lobectomy with 1356 of the 2554 patients who underwent open lobectomy, and compared their long-term survival outcomes. Findings: The mean age of the 2712 matched patients was 59 years (SD 11). After propensity matching, VATS and open lobectomy were similar with regard to important prognostic variables. In multivariate analysis, four prognostic factors were independently associated with improved survival: gender (p = 0.001), histological type (p < 0.001), pathological staging (p < 0.001), and surgery type (lobectomy/sleeve resection vs. pneumonectomy (p = 0.044). Patients who underwent VATS versus open lobectomy had similar long-term survival (p = 0.101). Interpretation: The current propensity-score analysis suggests that well-matched patients with NSCLC who underwent VATS lobectomy did not have inferior long-term survival outcomes compared with those who underwent open lobectomy. Funding: National Natural Science Foundation of China, Guangdong Province Science and Technology Planning Programme, Guangdong Province Science and Technology Key Programme, and Guangzhou City Science and Technology Planning Programme. The authors declared no conflicts of interest.