Abstract
Lys751Gln and nasopharyngeal carcinoma risk until now. The frequency of the XRCC1 codon 280 homozygous wild-type Arg/Arg genotype was 77.9% (88/113) in cases and 80.8% (105/130) in controls; the heterozygous Arg/His genotype was 21.3% (24/113) in cases and 18.5% (24/130) in controls; and the His/His genotype was 0.8% (1/113) in cases and 0.7% (1/130) in controls. For XRCC1 codon 280 polymorphisms, no significant association between Arg280His and risk of NPC was found (OR 1.30, 95% CI 0.66–2.57; p = 0.447). Interpretation: Risk of NPC was nearly two and a half times higher for individuals with the homozygous wild-type Lys/Lys genotype than for the heterozygous Lys/Gln genotype, adjusted for age, sex, and ethnicity. To our knowledge, there have been no documented reports of the association between XPDLys751Gln and nasopharyngeal carcinoma risk until now. Funding: Science Fund, Ministry of Science and Innovation, Malaysia. The authors declared no conflicts of interest.
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