OP12.01: The relationship of multiple peri‐conception risk factors and congenital heart disease: a retrospective study with 975 cases

Abstract

A retrospective study was carried out to explore the relationship between multiple risks during peri-conception and congenital heart disease (CHD). The clinical epidemiologic investigation was performed in 975 families during 2012.03 to 2012.12, which the children were done echocardiography in our department. Multiple factors were investigated including physical and chemical factors, infection and medication during peri-conception. Statistical significance was analyzed by chi-square test and logistic regression. Echocardiography showed that 778(79.8%) children were normal, and 197 children (20.2%) were diagnosed with CHD. Simple ventricular defect (n = 79), patent ductus arteriosus (n = 62), tetralogy of fallot (n = 31), double-outlet of right ventricle(n = 7) and transposition of the great arteries(n = 10) were the most common defects. Clinical epidemiology study had shown that, during the peri-conception, 27% of the parents had been exposed under chemical risk factors including working environment pollution, in-door air pollution and hair perm and dying. Among all the risk factors, there were strong correlation between CHD and chemical factors, infection and medication during pregnancy (p < 0.01). During the peri-conception, multiple risk factors may increase the incidence rate of CHD. Besides the well known risk factors like infection and medication, the chemical factors associated with the pollution such as hair perm and dyeing, in-door air pollution and the working environment pollution play a more and more important role in CHD formation. The relationship of multiple peri-conception risk factors and congenital heart disease: a retrospective study with 975 cases. OP12.01: Table