OP.1A.09] THE RELATIONSHIP BETWEEN THE AGGRESSION LEVEL OF PATIENTS WITH ARTERIAL HYPERTENSION AND THE ANTIHYPERTENSIVE DRUG EFFECTIVENESS

Abstract

Objective: The aim of study was to define relationships between psychological traits of patients with arterial hypertension (AH) and the antihypertensive drug effectiveness.Design and method: We analyzed ambulatory blood pressure monitoring (ABPM) data of 275 patients with AH without serious concomitant diseases We used data base of several studies with the same design: 1) the washout period duration - 1–2 weeks; 2) initial ABPM session (SpaceLabs 90207) before treatment; 3) treatment with standard therapeutic doses (amlodipin, diltiazem, metoprolol, betaxolol, enalapril, moxonidin, lisinopril) with the addition of diuretic if needed; 4) psychological status assessment was performed by the psychological questionnaire “Minnesota Multiphase Personality Inventory”(MMPI) before and at the end of the treatment. The antihypertensive therapy effectiveness (ATE) was assessed as the difference between mean ABPM levels before and after treatment. We used Spearman Partial Coefficient for correlation analysis adjusted for age, sex and duration of AH. Results: The initial mean daytime BP level was (M ± SD): systolic (SBP) - 140.1 ± 11.2, diastolic (DBP) - 90.2 ± 9.1 mmHg. We found following correlations (r) (p < 0.05): 1) negative – between ATE and leadership traits, aggression level (6 MMPI scale score) (r = −0,21) 2) positive - between ATE and optimism, cheerfulness (9 MMPI scale score) (0,20) (see table). Conclusions: Conclusion: Thus leadership traits, aggression had a negative correlation with the effect of antihypertensive treatment. While high optimism, cheerfulness level predict significantly better results of antihypertensive therapy.